Hydrochloric Acid → cis-2-[(4-Benzoxazol-2-yl)benzyloxy]cyclohexylamine hydrochloride
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:43]=[CH:42][C:13]([CH2:14][O:15][C@@H:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@@H:17]2[NH:22]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:12][CH:11]=1.[ClH:44]>C(O)C>[ClH:44].[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:43]=[CH:42][C:13]([CH2:14][O:15][C@H:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C@H:17]2[NH2:22])=[CH:12][CH:11]=1参加物
4
実験手順
Cis-1-[4-(benzoxazol-2-yl)benzyloxy]-2-triphenylmethylaminocyclohexane (2.03 g; 3.6 mmol) in 200 ml ethanol is treated with ethanolic HCl to pH 4 and stirred for 24 hrs. at room temperature. The solution is concentrated in vacuo, treated with ether and a white solid which precipitates out is filtered, washed with dry ether and dried in vacuo to obtain cis-2-[(4-benzoxazol-2-yl)benzyloxy]cyclohexylamine hydrochloride (m.p. 280°-281° C. dec).