Docos-21-yn-1-ol → Docos-21-ynoic Acid

HRID 2399982ノート

反応式

HRID 2399982 の反応式
[CH2:1]([OH:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[CH:22].CC(C)=[O:26].OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[C:1]([OH:26])(=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[CH:22]

参加物

4

反応物 2

HCID 57307871Docos-21-yn-1-olHCID 131709961Jones' reagent2 回

生成物 1

HCID 54502951Docos-21-ynoic Acid収率 83%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Docos-21-ynol (12 g, 0.037 mol) was dissolved in warm acetone (600 ml) treated with Jones reagent (20 ml). After stirring for 30 minutes tlc showed complete reaction so the excess Jones reagent was quenched with propane-2-ol and the volatile components removed in vacuo. The organic fractions were combined, dried (MgSO4), filtered and evaporated to leave docos-21-ynoic acid (32) as a pale green solid (10.4 g, 83%).

後処理

  1. customwas quenched with propane-2-ol
  2. customthe volatile components removed in vacuo
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-a634d028ac4e474888d468f3e253aee9
出典データセット
uspto-grants-1995_09
特許番号
US05451691

反応ノート

読み込み中…