4-Phenyl-1,2,3-thiadiazole-5-carboxylic acid → HCID 57130124、化合物
反応式
[NH2:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:15])([CH3:14])[C@H:3]1[OH:16].[C:17]1([C:23]2[N:24]=[N:25][S:26][C:27]=2[C:28](O)=[O:29])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CO>[C:12]([C:9]1[CH:10]=[CH:11][C:6]2[O:5][C:4]([CH3:14])([CH3:15])[C@@H:3]([OH:16])[C@H:2]([NH:1][C:28]([C:27]3[S:26][N:25]=[N:24][C:23]=3[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:29])[C:7]=2[CH:8]=1)#[N:13]参加物
4
実験手順
The title compound was prepared from (3S-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (the title B compound of Example 1) and 4-phenyl-1,2,3-thiadiazole-5-carboxylic acid by the same method as described for the title compound of Example 2 to give a colorless solid, m.p. 185° C. (decomposed). [α]D =-26.2° (c=0.80, MeOH).