Ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate → 3-Ethylaminomethyl-3-hydroxypyrrolidine
反応式
[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][N:7](C(OCC)=O)[CH2:6]1)[CH3:2]>O>[CH2:1]([NH:3][CH2:4][C:5]1([OH:15])[CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:2]参加物
3
実験手順
7.7 g (35.6 mmol) of ethyl 3-ethylaminomethyl-3-hydroxypyrrolidine-1-carboxylate are heated under reflux overnight with 22 g of Ba(OH)2 . 8H2O in 220 ml of water. The mixture is filtered off with suction from BaCO3 and concentrated. The residue is boiled five times using 100 ml of dioxane each time, and the dioxane solution is concentrated and distilled.
後処理
- filtrationThe mixture is filtered off with suction from BaCO3
- concentrationconcentrated
- concentrationthe dioxane solution is concentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-24145c24e110439ea0d37ab8abc38a9a
- 出典データセット
- uspto-grants-1995_09
- 特許番号
- US05453422
反応ノート
読み込み中…