Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

反応式

[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 19382159HCID 19382159、化合物

生成物 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

実験手順

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

後処理

concentrationThe product is concentrated
customthe crystals are triturated with acetone
filtrationfiltered off with suction
dry with materialdried in a vacuum desiccator over P4O10

出典と根拠

ORDレコード: ord-706161d1ccac428bbbe9cfaae2ef2e21
出典データセット: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05453422

反応ノート

読み込み中…

参加物