Hydrochloric Acid → 4-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

HRID 2400077ノート

反応式

HRID 2400077 の反応式
[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:2].[ClH:17]>>[ClH:17].[ClH:17].[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 19382186HCID 19382186、化合物

生成物 1

HCID 193821764-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

実験手順

4.6 g (20 mmol) of ethyl 4-ethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

後処理

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

出典と根拠

ORDレコード
ord-c0d7121fd6074758bc75edd21881b338
出典データセット
uspto-grants-1995_09
特許番号
US05453422

反応ノート

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