化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 5(2H)-Oxazolone, 4-(4-chlorophenyl)-2-(trifluoromethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Phosphorus trichloride | HCID 24387 | — |
| 反応物 | Trifluoroacetyl chloride | HCID 61106 | — |
| 反応物 | 2-((4-Chlorophenyl)amino)acetic acid | HCID 230717 | — |
| 生成物 | 5(2H)-Oxazolone, 4-(4-chlorophenyl)-2-(trifluoromethyl)- | HCID 11065291 | — |
反応手順
A solution of p-chlorophenylglycine (46.9 g, 0.25 mole) in a mixture of acetonitrile, xylenes and dimethyl formamide (74.8 w/w%, 24.9 w/w% and 0.3 w/w%, respectively) is treated sequentially with PCl3 (21.3 g, 0.155 mole) and trifluoroacetyl chloride (34.8 g, 0.26 mole), held at 40° C. for 0.5 hour, heated at 60° -65° C. for 8 hours and allowed to cool to room temperature. The title product is obtained in quantitative yield by HPLC analysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05453508 |
| 出典データセット | uspto-grants-1995_09 |
| ORD ID | ord-6e69ef7220c84e688f426d9d2773d60b |
| 出典メモ | uspto-grants-1995_09 |