2,2-Dimethyl-1,3-dioxane-4,6-dione → 8-fluoro-2-oxo-2H-chromene-3-carboxylic acid
反応式
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[C:3]=1[OH:10].CC1(C)O[C:17](=[O:18])[CH2:16][C:14](=[O:15])[O:13]1>O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]2[C:3]=1[O:10][C:17](=[O:18])[C:16]([C:14]([OH:15])=[O:13])=[CH:5]2参加物
4
反応条件
- 温度
- 75 °C
実験手順
3-Fluorosalicylaldehyde (97.2 mg, 0.69 mmol) and Meldrum's acid (100 mg, 0.69 mmol) were combined in H2O (1 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 99.6 mg of 8-fluoro-3-carboxy-coumarin in a 68% yield.
後処理
- temperatureAfter cooling to room temperature
- filtrationthe precipitate was filtered
- customdried at suction
出典と根拠
- ORDレコード
- ord-bd1e131ce76045d8bb167a89b6867b34
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642788B2
反応ノート
読み込み中…