Ammonia → 2-Chloro-5-methoxypyrimidin-4-amine

HRID 2400339ノート

反応式

HRID 2400339 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH3:10])=[CH:4][N:3]=1.[NH3:11]>CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:11])[C:5]([O:9][CH3:10])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 6014012,4-Dichloro-5-methoxypyrimidine

生成物 1

HCID 569495382-Chloro-5-methoxypyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45 g, 2.5 mmol) and ammonia in methanol (2N, 20 ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+=160

後処理

  1. concentrationThe mixture was then concentrated in vacuo
  2. washwashed with water
  3. customThe residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether)

出典と根拠

ORDレコード
ord-e3a34c5197bd42178377e0d632b1b333
出典データセット
uspto-grants-2014_08
特許番号
US08796244B2

反応ノート

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