関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| 反応物 | 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde | HCID 1268058 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acid | HCID 10061868 | 50% |
反応手順
5-trifluoromethoxy-salicylaldehyde (286.0 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 189.1 mg of 6-trifluoromethoxy-3-carboxy-coumarin in a 50% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08642788B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-75c7661c2c424a7abc926de33611af6d |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
