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Diisopropylethylamine → 6-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-(Imidazo(1,2-a)pyridin-2-yl)aniline | HCID 697021 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 6-(Trifluoromethoxy)-2-oxo-2H-chromene-3-carboxylic acid | HCID 10061868 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Trifluoromethoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide | HCID 44197385 | 36.4% |
反応手順
DIEA (34.9 μL, 0.20 mmol) was added to 6-trifluoromethoxy-3-carboxy-coumarin (50.0 mg, 0.18 mmol) and HATU (76.3 g, 0.20 mmol) in 1 mL of DMF with constant stirring at room temperature until a clear solution resulted. Subsequently, 3-Imidazo[1,2-a]pyridin-2-yl-phenylamine (38.2 mg, 0.18 mmol) was added and allowed to react overnight when a solid precipitated out of solution. The resulting precipitate was filtered, dried under suction, and finally dried overnight in vacuo to give 30.5 mg of product in 36% yield: LCMS (ESI) m/z 466 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642788B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-18d13d9d0b4e486d89f2d2dda2ec1f66 |
| 出典メモ | uspto-grants-2014_02 |