2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-Iodo-3-carboxy-coumarin
反応式
[I:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.CC1(C)O[C:17](=[O:18])[CH2:16][C:14](=[O:15])[O:13]1>O>[I:1][C:2]1[CH:9]=[C:6]2[C:5](=[CH:4][CH:3]=1)[O:10][C:17](=[O:18])[C:16]([C:14]([OH:15])=[O:13])=[CH:7]2参加物
4
反応条件
- 温度
- 75 °C
実験手順
5-iodosalicylaldehyde (344.2 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 302.0 mg of 6-iodo-3-carboxy-coumarin in 69% yield.
後処理
- temperatureAfter cooling to room temperature
- filtrationthe precipitate was filtered
- customdried at suction
出典と根拠
- ORDレコード
- ord-fd89cebea6e1418f82f7f52836e62dc4
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642788B2
反応ノート
読み込み中…