Bromine → N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide

HRID 2400941ノート

反応式

HRID 2400941 の反応式
[F:1][C:2]1[C:3]([CH3:12])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Br:13]Br>C(O)(=O)C>[Br:13][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:3]([CH3:12])[C:2]=1[F:1]

参加物

4

反応物 2

HCID 24408BromineHCID 1489284N-(3-fluoro-2-methylphenyl)acetamide

生成物 1

HCID 67123438N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of N-(3-Fluoro-2-methylphenyl)acetamide (39 mmol) in acetic acid (50 mL) was added bromine (40 mmol) in dropwise fashion. After stirring at rt for 2 days, the precipitated product was filtered, washed with water, and dried under high vacuum. N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide was obtained as a white solid.

後処理

  1. filtrationthe precipitated product was filtered
  2. washwashed with water
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-821875d27e5f4b619e1cbcb7213e5098
出典データセット
uspto-grants-2014_08
特許番号
US08796256B2

反応ノート

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