2,3-Dichloropyrazine → N-(3-chloropyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide

HRID 2401023ノート

反応式

HRID 2401023 の反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[F:9][C:10]([F:22])([F:21])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17]([NH2:20])(=[O:19])=[O:18]>>[Cl:8][C:7]1[C:2]([NH:20][S:17]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10]([F:9])([F:22])[F:21])(=[O:18])=[O:19])=[N:3][CH:4]=[CH:5][N:6]=1

参加物

3

反応物 2

HCID 785752,3-DichloropyrazineHCID 27780182-(Trifluoromethyl)benzenesulfonamide

生成物 1

HCID 57586069N-(3-chloropyrazin-2-yl)-2-(trifluoromethyl)benzenesulfonamide収率 63%

実験手順

Following the general method as outlined for Intermediate 2, starting from 2,3-dichloropyrazine and 2-(trifluoromethyl)benzenesulfonamide, the title compound was isolated, after evaporation and recrystallization, as a yellowish solid in 63% yield (97% purity by HPLC).

出典と根拠

ORDレコード
ord-72f8f967d4ed45618f5e18c914d36c64
出典データセット
uspto-grants-2014_08
特許番号
US08796280B2

反応ノート

読み込み中…