化工社化工社 化学情報印刷レポート · 研究参考用
N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | HCID 15563630 | HCID 15563630 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine | HCID 86677016 | 81% |
反応手順
11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08796284B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-ab2294b0b0e240c9a93440f63ec30081 |
| 出典メモ | uspto-grants-2014_08 |