Ammonia → HCID 178513697、化合物

HRID 2401177ノート

反応式

HRID 2401177 の反応式
[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10]CC)=O)[CH:3]=1.[NH3:13]>>[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH2:13])=[O:10])[CH:3]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 178469368HCID 178469368、化合物2 回

生成物 1

HCID 178513697HCID 178513697、化合物収率 68.4%

実験手順

Ethyl 6-hydroxy-4-pyrimidinecarboxylate (Intermediate 6, 0.995 g, 5.92 mmol) was treated with 0.88 ammonia solution (9.95 mL, 460 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 18 hours. The resulting solid was collected by filtration, taken up in toluene and the solvent removed under reduced pressure to give the title compound as a yellow solid (563 mg);

後処理

  1. filtrationThe resulting solid was collected by filtration
  2. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-8707f8fbf2ae48cd97769a773ef24e81
出典データセット
uspto-grants-2014_08
特許番号
US08796283B2

反応ノート

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