Hydrochloric Acid → 1-(6-Chloropyrimidin-4-yl)ethan-1-one

HRID 2401189ノート

反応式

HRID 2401189 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]CC)=[CH2:9])[N:5]=[CH:4][N:3]=1.Cl>CC(C)=O>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 865947284-Chloro-6-(1-ethoxyvinyl)pyrimidine2 回

生成物 1

HCID 722142471-(6-Chloropyrimidin-4-yl)ethan-1-one収率 76.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4-Chloro-6-[1-(ethyloxy)ethenyl]pyrimidine (Intermediate 17, 3.54 g, 19.17 mmol) was dissolved in acetone (177 mL), treated with 2M aqueous hydrochloric acid solution (28.8 mL, 57.5 mmol) and the resulting mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure. The residue was neutralised with aqueous saturated sodium bicarbonate solution and extracted with ethyl acetate (×2). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a white solid (2.30 g);

後処理

  1. customThe solvent was removed under reduced pressure
  2. extractionextracted with ethyl acetate (×2)
  3. customdried under magnesium sulfate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-a7553d8829d3406b8e834eeafe3f7f94
出典データセット
uspto-grants-2014_08
特許番号
US08796283B2

反応ノート

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