2,2-Dimethyl-1,3-dioxane-4,6-dione → HCID 21883483、化合物

HRID 240202ノート

反応式

HRID 240202 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.CC1(C)O[C:16](=O)[CH2:15][C:13](=[O:14])[O:12]1>O>[NH:1]1[C:2]2[C:3](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:15]([C:13]([OH:14])=[O:12])[CH2:16]1

参加物

4

反応物 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 682552-Aminobenzaldehyde

生成物 1

HCID 21883483HCID 21883483、化合物収率 71.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

2-Aminobenzaldehyde (84.1 mg, 0.69 mmol) and Meldrum's acid (100 mg, 0.69 mmol) were combined in H2O (1 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 86.2 mg of 1,2-dihydro-quinoline-3-carboxylic acid with a yield of 66%.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe precipitate was filtered
  3. customdried at suction

出典と根拠

ORDレコード
ord-5ef52b34e05c4e4fa46203c4166b41d0
出典データセット
uspto-grants-2014_02
特許番号
US08642788B2

反応ノート

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