関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 2-Amino-p-benzenedisulfonic acid | HCID 60988 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Phthalonitrile | HCID 7042 | — |
反応手順
A solution of aniline 2,5 disulphonic acid (27.5 g) in water (250 ml) was added to intermediate E (63.2 g) in acetonitrile (800 ml) and heated at 40° C. and at pH 5 to 7 overnight. The reaction solvent was removed under reduced pressure, water (50 ml) was added and then brine (60 ml) the solid which precipitated of filtered off, washed with 10% brine and dried to give product (91.1% strength, 22 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08647425B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-fe1ef58b8c64429ab6caf2f77af6a2c5 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
