4-Fluorobenzylamine → HCID 67482556、化合物
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:12])[NH:5][C:6]2=[O:11].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]N)=[CH:16][CH:15]=1>C(O)(=O)C>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:12])[N:5]([CH2:18][C:17]1[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=1)[C:6]2=[O:11]参加物
4
反応条件
- 温度
- 150 °C
実験手順
A mixture of 4-chloro-isoindole-1,3-dione (2.75 g, 15 mmol) and 4-fluorobenzylamine (1.88 g, 15 mmol) in glacial acetic acid (10 mL) was heated at 150° C. in microwave for 30 mins. After cooled to room temperature, the reaction mixture was poured into ice water and the white precipitates were collected. Recrystallization with EtOH provided the title compound (3.86 g, 89%).
後処理
- temperatureAfter cooled to room temperature
- customthe white precipitates
- customwere collected
- customRecrystallization with EtOH
出典と根拠
- ORDレコード
- ord-f8c12a5b93474e49a8919040bfbe3b97
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08796313B2
反応ノート
読み込み中…