Ammonium Hydroxide → 1-(2-Aminopyridin-5-yl)ethanone
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[NH4+:11].[OH-]>O>[NH2:11][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1参加物
4
実験手順
1-(6-Chloropyridin-3-yl)-ethanone (230 mg, 1.5 mmol), 1 mL 28% aq NH4OH, and catalytic CuSO4.5H2O were heated to 130° C. in a sealed tube for 5 h. The mixture was cooled, diluted with 20 mL water, and washed with 2×25 mL EtOAc. The combined organics were washed with brine, dried (MgSO4), filtered, and evaporated. The title compound was obtained by silica gel chromatography (163 mg, 80%).
後処理
- temperatureThe mixture was cooled
- washwashed with 2×25 mL EtOAc
- washThe combined organics were washed with brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-3e7affed67e84349b21b16f6588d62be
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08796313B2
反応ノート
読み込み中…