Phenol → Phenyl 4-methylpentanoate

HRID 240236ノート

反応式

HRID 240236 の反応式
[CH3:1][CH:2]([CH3:8])[CH2:3][CH2:4][C:5](Cl)=[O:6].[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O>[CH3:1][CH:2]([CH3:8])[CH2:3][CH2:4][C:5]([O:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6]

参加物

4

反応物 2

HCID 996PhenolHCID 170008Pentanoyl chloride, 4-methyl-

生成物 1

HCID 12653656Phenyl 4-methylpentanoate収率 88%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4-Methylpentanoyl chloride (3.0 g, 22.3 mmol) was added dropwise to phenol (2.1 g, 22.3 mmol). After 3 hours, H2O was added and the reaction mixture was extracted with Et2O. The organic phase was washed with NaHCO3, then brine to neutrality, then dried (Na2SO4), concentrated and bulb-to-bulb distilled to afford the title compound in 88% yield.

後処理

  1. extractionthe reaction mixture was extracted with Et2O
  2. washThe organic phase was washed with NaHCO3
  3. dry with materialbrine to neutrality, then dried (Na2SO4)
  4. concentrationconcentrated
  5. distillationbulb-to-bulb distilled

出典と根拠

ORDレコード
ord-2fdca11ac0de4538881cd3f7ef310dc2
出典データセット
uspto-grants-2014_02
特許番号
US08648032B2

反応ノート

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