Urea → 2(1H)-Quinazolinone, 4-phenyl-

HRID 2402489ノート

反応式

HRID 2402489 の反応式
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[NH2:16][C:17](N)=[O:18]>C(O)(=O)C>[C:6]1([C:4]2[C:3]3[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=3)[NH:1][C:17](=[O:18])[N:16]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 1176UreaHCID 760802-Aminobenzophenone

生成物 1

HCID 634302(1H)-Quinazolinone, 4-phenyl-

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2-aminobenzophenone (100 g, 0.51 mol), urea (55 g, 0.93 mol) and acetic acid (300 mL) was stirred at 110° C. for 18 h. The reaction mixture was cooled to rt and filtered. The solid was washed with water and dried under reduced pressure. 4-Phenylquinazolin-2(1H)-one was isolated as a yellow solid and was used without further purification.

後処理

  1. filtrationfiltered
  2. washThe solid was washed with water
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-5e6bc59a132f4c528fd40c30cf3c7c32
出典データセット
uspto-grants-2014_08
特許番号
US08796294B2

反応ノート

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