Bromine → 2-Bromo-1-(4-fluoro-3-methylphenyl)ethanone

HRID 2402731ノート

反応式

HRID 2402731 の反応式
[Br:1]Br.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][C:5]=1[CH3:13]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:7]1[CH:8]=[CH:9][C:4]([F:3])=[C:5]([CH3:13])[CH:6]=1)=[O:12]

参加物

4

反応物 2

HCID 24408BromineHCID 2893281-(4-Fluoro-3-methylphenyl)ethan-1-one

生成物 1

HCID 109773012-Bromo-1-(4-fluoro-3-methylphenyl)ethanone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

0.67 mL bromine was added to 2 g 1-(4-fluoro-3-methyl-phenyl)-ethanone in 10 mL conc. acetic acid. The reaction was stirred 3 h at RT. The mixture was added to ice water. The precipitate was filtered, washed with water and dried to give 2.7 g desired product. Rt: 1.10 min (method A), (M+H)+: 231

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-b2bdef4bf7c54a74a6e3da2508fc951c
出典データセット
uspto-grants-2014_08
特許番号
US08796467B2

反応ノート

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