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Methanol → 2-Bromo-5-fluorobenzyl alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzoic acid, 2-bromo-5-fluoro-, methyl ester | HCID 138875 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Bromo-5-fluorobenzyl alcohol | HCID 2773349 | — |
反応手順
To a solution of methyl 2-bromo-5-fluorobenzoate (10, 21.30 g, 91.4 mmol) in dry THF (150 mL) was added NaBH4 (6.95 g, 183 mmol). Methanol (20 mL) was added dropwise at RT. After the addition, the mixture was stirred at RT for 1 h. Water (200 mL) was slowly added. The mixture was extracted with CH2Cl2 (100 mL×2). The combined extracts were washed with saturated NaHCO3 and brine, dried over MgSO4 and concentrated to give (2-bromo-5-fluorophenyl)methanol (11).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648073B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-f680df50dc154f649f0aca6fe6f78b8d |
| 出典メモ | uspto-grants-2014_02 |