Hydrochloric Acid → HCID 86659851、化合物

反応式

[OH:1][CH:2]1[C@@H:9]2[C@@H:5]([CH2:6][N:7](C(OC(C)(C)C)=O)[CH2:8]2)[CH2:4][CH:3]1[N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.Cl.O1CCOCC1>>[N:17]1([CH:3]2[CH2:4][C@@H:5]3[CH2:6][NH:7][CH2:8][C@@H:9]3[CH:2]2[OH:1])[CH:21]=[CH:20][N:19]=[CH:18]1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 86659850HCID 86659850、化合物

生成物 1

HCID 86659851HCID 86659851、化合物

実験手順

In a 4 mL vial were combined (3aR,6aS)-tert-butyl 4-hydroxy-5-(1H-imidazol-1-yl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (50 mg, 0.170 mmol) from Step 3 and 4 N HCl in 1,4-dioxane (0.554 mL, 2.216 mmol) to give a suspension. The reaction was stirred at room temperature for 6 hours, and then the solvent was removed in vacuo. The resulting HCl salt was triturated with 3 mL of 10% methanol (2 N ammonia)/dichloromethane and filtered to give crude (3aR,6aS)-5-(1H-imidazol-1-yl)octahydrocyclopenta[c]pyrrol-4-ol: MS (ESI+) m/z 398 (M+H)+.

後処理

customto give a suspension
customthe solvent was removed in vacuo
customThe resulting HCl salt was triturated with 3 mL of 10% methanol (2 N ammonia)/dichloromethane
filtrationfiltered

出典と根拠

ORDレコード: ord-886ef3faf5b641a5919e5332c3f3d20f
出典データセット: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08796470B2

反応ノート

読み込み中…

参加物