Hydrochloric Acid → Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

HRID 2402812ノート

反応式

HRID 2402812 の反応式
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]([NH:17]C(=O)OC(C)(C)C)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])[CH:6]=[CH:7][CH:8]=1.[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[NH2:17][CH:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:26])[CH:4]=1)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59536750tert-Butyl ethyl {1-[3-(trifluoromethyl)phenyl]ethane-1,2-diyl}biscarbamate

生成物 1

HCID 86646633Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 527 mg (1.40 mmol) of the compound from Example 103A in 9.6 ml of dichloromethane was admixed at RT with 9.4 ml (37 mmol) of 4M hydrogen chloride in dioxane and stirred for 1 h. Then all of the volatile constituents were removed on a rotary evaporator. Drying of the residue in an HV gave 437 mg (94% of theory) of the title compound.

後処理

  1. customThen all of the volatile constituents were removed on a rotary evaporator
  2. customDrying of the residue in an HV

出典と根拠

ORDレコード
ord-11f5e1c0558048649c792da26504f3dc
出典データセット
uspto-grants-2014_08
特許番号
US08796324B2

反応ノート

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