関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 9-oxo-9H-indeno(1,2-b)pyrazine-2,3-dicarbonitrile | HCID 292929 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 生成物 | 9-hydroxy-3-methoxy-9H-indeno[1,2-b]pyrazine-2-carbonitrile | HCID 16065352 | 53% |
反応手順
To a suspension of 1 (150 mg, 0.646 mmol) in MeOH (6.5 ml), cooled at 0° C., NaBH4 (24 mg, 0.646 mmol) was added. After 30 min, water (5 ml) was added, MeOH was evaporated and the residue was extracted with CH2Cl2 (3×5 ml). The organic layers were dried over Na2SO4, filtered and evaporated. EtOH was added and the precipitate was collected by filtration affording 2 (82 mg, 53%) as white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08648076B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-53bbcc47733a4da5a71f65262cc9e700 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
