Hydrochloric Acid → (4,5-Dichloro-6-piperazin-1-yl-pyrimidin-2-yl)-methyl-amine dihydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[C:18]([Cl:21])[N:17]=[C:16]([NH:22][CH3:23])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>C(OC(=O)C)C>[ClH:20].[ClH:24].[Cl:21][C:18]1[C:19]([Cl:20])=[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:15]=[C:16]([NH:22][CH3:23])[N:17]=1参加物
4
実験手順
2.6 g (7.2 mmol) 4-(5,6-dichloro-2-methylamino-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester was deprotected at 10° C. using 100 ml ethylacetate saturated with gaseous hydrochloric acid. After 4 hours the precipitate was filtered giving the title compound (2.4 g, 100%), melting at 204-209° C.
後処理
- customwas deprotected at 10° C.
- filtrationAfter 4 hours the precipitate was filtered
出典と根拠
- ORDレコード
- ord-4296734c163e42e7bcee34af394c9516
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08802672B2
反応ノート
読み込み中…