1-Isopropyl-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one → Tert-butyl 2-(2-chloro-3-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-ylcarbonyl)quinolin-6-yloxy)acetate

HRID 2403700ノート

反応式

HRID 2403700 の反応式
[C:1]([O:5][C:6](=[O:23])[CH2:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]=[C:14]([Cl:19])[C:13]([C:20]([OH:22])=O)=[CH:12]2)([CH3:4])([CH3:3])[CH3:2].[CH:24]([N:27]1[C:40]2[C:39](=[O:41])[CH2:38][C:32]3([CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)[CH2:31][C:30]=2[CH:29]=[N:28]1)([CH3:26])[CH3:25]>>[Cl:19][C:14]1[C:13]([C:20]([N:35]2[CH2:34][CH2:33][C:32]3([CH2:38][C:39](=[O:41])[C:40]4[N:27]([CH:24]([CH3:26])[CH3:25])[N:28]=[CH:29][C:30]=4[CH2:31]3)[CH2:37][CH2:36]2)=[O:22])=[CH:12][C:11]2[C:16](=[CH:17][CH:18]=[C:9]([O:8][CH2:7][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:23])[CH:10]=2)[N:15]=1

参加物

3

反応物 2

HCID 573370671-Isopropyl-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-oneHCID 866728696-(2-Tert-butoxy-2-oxoethoxy)-2-chloroquinoline-3-carboxylic acid

生成物 1

HCID 86672873Tert-butyl 2-(2-chloro-3-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-ylcarbonyl)quinolin-6-yloxy)acetate

実験手順

6-(2-tert-butoxy-2-oxoethoxy)-2-chloroquinoline-3-carboxylic acid and 1-isopropyl-4,6-dihydrospiro[indazole-5,4′-piperidin]-7(1H)-one were coupled by a method analogous to that described for Example 1 to give tert-butyl 2-(2-chloro-3-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-ylcarbonyl)quinolin-6-yloxy)acetate. This material (30 mg, 0.053 mmol) was suspended in ammonia (2 mL, 10 mmol, 7 M in methanol) and stirred at room temperature for 18 hours. The reaction was concentrated to give the title compound (27 mg, 100%). +ESI (M+H) 510.4.

出典と根拠

ORDレコード
ord-2240b09812c547a39bf8ad13039ab58a
出典データセット
uspto-grants-2014_08
特許番号
US08802688B2

反応ノート

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