phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate → 2-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

HRID 2403848ノート

反応式

HRID 2403848 の反応式
C(OC1N=C2C(N=C(OC)N2CCCC2CCCCN2)=C(N)N=1)CCC.[NH2:27][C:28]1[N:36]=[C:35]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[N:34]=[C:33]2[C:29]=1[N:30]=[C:31]([O:60][CH3:61])[N:32]2[CH2:42][CH2:43][CH:44]1[CH2:49][CH2:48][N:47](C(OCC2C=CC=CC=2)=O)[CH2:46][CH2:45]1>>[CH2:38]([O:37][C:35]1[N:34]=[C:33]2[C:29]([N:30]=[C:31]([O:60][CH3:61])[N:32]2[CH2:42][CH2:43][CH:44]2[CH2:45][CH2:46][NH:47][CH2:48][CH2:49]2)=[C:28]([NH2:27])[N:36]=1)[CH2:39][CH2:40][CH3:41]

参加物

3

反応物 2

HCID 58306071phenylmethyl 4-{[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylateHCID 583061842-(Butyloxy)-8-(methyloxy)-9-[3-(2-piperidinyl)propyl]-9H-purin-6-amine

生成物 1

HCID 583062442-(Butyloxy)-8-(methyloxy)-9-[2-(4-piperidinyl)ethyl]-9H-purin-6-amine

実験手順

Prepared similarly to Intermediate 32 from phenylmethyl 4-{2-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]ethyl}-1-piperidinecarboxylate.

出典と根拠

ORDレコード
ord-0f7ecf2dfec740ae8c042fc6892c4f32
出典データセット
uspto-grants-2014_08
特許番号
US08802684B2

反応ノート

読み込み中…