Ethanol hydrochloride → 4-[(4-Fluorophenyl)methyl]piperidin-4-ol hydrochloride
反応式
[F:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][C:7]2([OH:20])[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[ClH:23].C(O)C>C(O)C>[ClH:23].[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2([OH:20])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[CH:21][CH:22]=1参加物
4
実験手順
To a solution of tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate (2.0 g) in ethanol (10 mL) was added 2.0 M HCl/ethanol solution (20 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethanol/hexane to give the title compound (1.4 g).
後処理
- customThe solvent was evaporated under reduced pressure
- customthe obtained solid was recrystallized from ethanol/hexane
出典と根拠
- ORDレコード
- ord-5fd01f27640743fa95dd90c5ca4a97a7
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08648079B2
反応ノート
読み込み中…