Hydrochloric Acid → 2-(Pyrimidin-4-yl)nicotinic acid dihydrochloride
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1参加物
4
実験手順
A mixture of methyl 2-(pyrimidin-4-yl)nicotinate (0.19 g), acetic acid (1.0 mL) and 6 N hydrochloric acid (5 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure to give the title compound (0.26 g).
後処理
- temperaturewas heated
- temperatureunder reflux for 5 hr
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-b824635fb4ec44e19f1d313ed721598b
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08648079B2
反応ノート
読み込み中…