化工社化工社 化学情報印刷レポート · 研究参考用
Diclofensine → Tartrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diclofensine | HCID 68871 | — |
| 反応物 | 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt | HCID 117729042 | — |
| 生成物 | Tartrate | HCID 119400 | — |
| 生成物 | 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt | HCID 117729042 | — |
反応手順
The L-tartrate of the (−)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline was prepared using (−)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline following similar steps described for the synthesis of the (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-tartrate salt ([α]24D-6.0° (c 0.10, methanol)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08802696B2 |
| 出典データセット | uspto-grants-2014_08 |
| ORD ID | ord-080f4c0bf0ee482c9143365b7c1908a0 |
| 出典メモ | uspto-grants-2014_08 |