1,4-Dioxane → 3-(1-[6-(4-tert-Butyl-cyclohexyloxy)-naphthalen-2-yl]-2,2,2-trifluoro-ethylamino)-propionic acid methyl ester
反応式
[C:1]([O:5][C:6](=[O:36])[CH2:7][CH2:8][NH:9][CH:10]([C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[C:20]([O:25][CH:26]3[CH2:31][CH2:30][CH:29]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:28][CH2:27]3)[CH:21]=2)[CH:16]=1)[C:11]([F:14])([F:13])[F:12])(C)(C)C.O1CCOCC1>Cl>[CH3:1][O:5][C:6](=[O:36])[CH2:7][CH2:8][NH:9][CH:10]([C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[C:20]([O:25][CH:26]3[CH2:27][CH2:28][CH:29]([C:32]([CH3:34])([CH3:33])[CH3:35])[CH2:30][CH2:31]3)[CH:21]=2)[CH:16]=1)[C:11]([F:14])([F:13])[F:12]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
3-{1-[6-(4-tert-Butyl-cyclohexyloxy)-naphthalen-2-yl]-2,2,2-trifluoro-ethylamino}-propionic acid tert-butyl ester (0.174 g, 0.343 mmol) was dissolved in 4 M of Hydrogen chloride in 1,4-Dioxane (3 mL, 10 mmol) and stirred at RT for 2.5 hrs. ALL solvent is removed after purification of the previous step. Reaction was then concentrated to dryness under reduced pressure to give the title compound which was taken directly to the next step.