Hydrochloric Acid → (8aS)-7-(3-fluorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one hydrochloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][C@@H:8]2[CH2:7]1.[ClH:26]>O1CCOCC1>[ClH:26].[F:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][CH:6]1[C:21](=[O:22])[N:9]2[CH2:10][CH2:11][NH:12][CH2:13][C@@H:8]2[CH2:7]1参加物
4
実験手順
To a solution of the product from Example 213A (72 mg, 0.207 mmol) in 1,4-dioxane (1 mL) was added a 4 M solution of hydrogen chloride in 1,4-dioxane (1 mL, 4.0 mmol). The resulting mixture was stirred at room temperature for 90 minutes and concentrated and dried in vacuo to give the title compound (59 mg, quantitative).
後処理
- concentrationconcentrated
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-7b0037ba3d0547a6810ccc0a6c7c0db7
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08648074B2
反応ノート
読み込み中…