化工社化工社 化学情報印刷レポート · 研究参考用
4-Nitro-1H-indole → 4-Aminoindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitro-1H-indole | HCID 145766 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Aminoindole | HCID 583431 | — |
反応手順
A round-bottom flask was charged with 4-nitroindole (4.8 g, 30 mmol), Palladium on carbon (10%, 480 mg), and THF (50 mL), and the mixture was stirred under one hydrogen atmosphere overnight. TLC showed the reaction was complete. The catalyst was filtered off and the filtrate was concentrated to afford 4-amino-1H-indole, which was used directly in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648086B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-c9141032da62429ea72e176f8ff59e25 |
| 出典メモ | uspto-grants-2014_02 |