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4-Chloro-2-isocyanato-1-methoxybenzene → 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-2-isocyanato-1-methoxybenzene | HCID 144009 | — |
| 反応物 | 4-Aminoindole | HCID 583431 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea | HCID 66613510 | 70% |
反応手順
A solution of 5-chloro-2-methoxyphenyl isocyanate (Int-4, 5.5 g, 30 mmol) in DCM (20 mL) was added dropwise to the 4-amino-1H-indole in DCM (30 mL) from Step A, and the resulting mixture was stirred overnight, then filtered to give the crude product 1-(5-chloro-2-methoxyphenyl)-3-(1H-indol-4-yl)urea (6.6 g, 70%), which was used directly in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08648086B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-de54c33bb23a4aabacae83b75d98320b |
| 出典メモ | uspto-grants-2014_02 |