ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → 2-(3-Fluoro-5-hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl ester

HRID 2405229
ノート
印刷プレビュー

反応式

HRID 2405229 の反応式
C([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([F:16])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=O)(=O)C.Cl.[CH3:18][O:19][C:20]([C:22]1([NH2:31])[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)=[O:21].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:18][O:19][C:20]([C:22]1([NH:31][C:8](=[O:10])[C:7]2[CH:6]=[C:5]([OH:4])[C:13]([O:14][CH3:15])=[C:12]([F:16])[CH:11]=2)[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23]1)=[O:21]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 45074056methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochlorideHCID 670767283-Acetoxy-5-fluoro-4-methoxy-benzoic acid

生成物 1

HCID 670766132-(3-Fluoro-5-hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl ester

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The compound of step 3 (120 mg, 0.526 mmol) was reacted with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 1 of example 15. The obtained product was dissolved in methanol (0.77 ml), potassium carbonate (2 mg) was added, and the mixture was stirred at room temperature for 30 min. The solvent was evaporated, the residue was partitioned between EA and a saturated sodium chloride solution, and the aqueous phase extracted with EA. The combined organic extracts were dried over sodium sulfate, filtered and evaporated to dryness to give 60 mg of the title compound.

後処理

  1. customThe solvent was evaporated
  2. customthe residue was partitioned between EA
  3. extractiona saturated sodium chloride solution, and the aqueous phase extracted with EA
  4. dry with materialThe combined organic extracts were dried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-3d13ac7024b14e68a731367bfe0fdbc5
出典データセット
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08802720B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート