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HRID 240528作成日：2026年10月26日

1,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate → (3aS,6aS)-tert-butyl 5-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[2,3-c]pyrrole-1(2H)-carboxylate

https://huagongshe.com/reaction/240528

反応式

関与物質

役割名称HCID仕込み量
反応物1,1-Dimethylethyl (3aS,6aS)-hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylateHCID 29949089—
反応物5-bromo-N-(3,5-difluorophenyl)nicotinamideHCID 41601149—
生成物(3aS,6aS)-tert-butyl 5-(5-(3,5-difluorophenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[2,3-c]pyrrole-1(2H)-carboxylateHCID 67265843—

反応手順

The product from Example 53A and (3aS,6aS)-tert-butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate (prepared as described in WO2001081347) were processed as described in Example 53B to provide the title compound. MS (APCI) m/z=445 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08648084B2
出典データセットuspto-grants-2014_02
ORD IDord-675ac849444c474f85b701a72f53dd1d
出典メモuspto-grants-2014_02