Chlorosuccinimide → HCID 59756645、化合物

HRID 2405751ノート

反応式

HRID 2405751 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2.[Cl:13]N1C(=O)CCC1=O>CN(C=O)C>[NH2:1][C:2]1[C:3]([Cl:13])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 513420016-Amino-1,2-dihydroisoquinolin-1-one

生成物 1

HCID 59756645HCID 59756645、化合物収率 82.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 0.500 g (3.12 mmol) of 6-amino-2H-isoquinolin-1-one in DMF (30 mL) was added 0.45 g (3.4 mol) of N-chlorosuccinimide. The mixture was stirred at room temperature for 15 h then poured over ice and stirred until all the ice was melted during which time a solid precipitated from solution. The tan solid was collected by filtration, washed with water and dried on the filter pad to provide 0.50 g (82% yield) of the title compound. MS calc. for C9H8ClN2O [M+H]+: 195.63. Found: 195.23.

後処理

  1. additionthen poured over ice
  2. customprecipitated from solution
  3. filtrationThe tan solid was collected by filtration
  4. washwashed with water
  5. customdried on the filter pad

出典と根拠

ORDレコード
ord-58f28356a7134552ad67b463146e57a6
出典データセット
uspto-grants-2014_08
特許番号
US08809326B2

反応ノート

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