Propanoic acid, 3-ethoxy-3-imino-, ethyl ester → 3-Ethoxy-3-(3-methoxy-2-methyl-phenylimino)-propionic acid ethyl ester
反応式
[CH3:1][O:2][C:3]1[C:4]([CH3:10])=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].[CH2:11]([O:13][C:14](=N)[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH3:12]>CCO>[CH2:19]([O:18][C:16](=[O:17])[CH2:15][C:14]([O:13][CH2:11][CH3:12])=[N:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([O:2][CH3:1])[C:4]=1[CH3:10])[CH3:20]参加物
4
実験手順
To 3-methoxy-2-methylaniline (2.15 g, 15.6 mmol) in anhydrous EtOH (30 mL) was added ethyl 3-ethoxy-3-imino-propionate (3.05 g, 15.6 mmol). The reaction was stirred overnight then filtered through celite. The filtrate was concentrated then purified by column chromatography on silica (2→10% EtOAc/hexane) to afford 3-ethoxy-3-(3-methoxy-2-methyl-phenylimino)-propionic acid ethyl ester (3.84 g, 88%). LCMS found 280.2 [M+H]+.