Hydrochloric Acid → Benzo[b]thiophen-2-amine hydrochloride
反応式
C(OC(=O)[NH:7][C:8]1[S:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[CH:9]=1)(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[S:12]1[C:8]([NH2:7])=[CH:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]1=2参加物
4
実験手順
Compound 1-B (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL), and the mixture was stirred at rt until all the starting material was consumed. The mixture was diluted with diethyl ether, the product collected by filtration, and washed with diethyl ether, to afford compound 1-C as an off-white solid (0.89 g, 83%). 1H-NMR (DMSO-d6): δ 6.43 (s, 1H), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, 1H) and 7.20 (m, 1H), 7.45 (d, 1H), 7.66 (d, 1H); MS: m/z 150.1 (MH+).
後処理
- customwas consumed
- additionThe mixture was diluted with diethyl ether
- filtrationthe product collected by filtration
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-2e01fff0fd5445198a2aa660059ee9a1
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809327B2
反応ノート
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