化工社化工社 化学情報印刷レポート · 研究参考用
HRID 240596作成日：2026年10月27日
5-Fluoro-2-nitrophenol → (2S,4S)-1-tert-butyl 2-methyl 4-(5-fluoro-2-nitrophenoxy)pyrrolidine-1,2-dicarboxylate
https://huagongshe.com/reaction/240596
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | (2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester | HCID 2734883 | — |
| 反応物 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2S,4S)-1-tert-butyl 2-methyl 4-(5-fluoro-2-nitrophenoxy)pyrrolidine-1,2-dicarboxylate | HCID 58413039 | — |
反応手順
Diethylazodicarboxylate (1.76 ml) was added dropwise to a solution of N-Boc-trans-4-hydroxy-L-proline methyl ester (2.74 g), 5-fluoro-2-nitrophenol (1.47 g) and triphenylphosphine (2.93 g) in dichlormethane under cooling at 0° C. The coolant was removed after 20 min and the reaction mixture was stirred at room temperature over the weekend. The solvent was evaporated and the residue war purified by chromatography to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08648068B2 |
|---|
| 出典データセット | uspto-grants-2014_02 |
|---|
| ORD ID | ord-c3706526ba5e40f2a807010243d86d46 |
|---|
| 出典メモ | uspto-grants-2014_02 |
|---|
