Hydrochloric Acid → 4-[(4-Chlorophenyl)methyl]-4-piperidinemethanamine
反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([C:14]#[N:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][C:11]2([CH2:14][NH2:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:18][CH:19]=1参加物
5
実験手順
To a solution of 4-(4-chlorobenzyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester (0.500 g, 1.493 mmol) in methanol (3 ml) was added 4M HCl in dioxane (10 ml). After stirring for 19 hours, the solution was concentrated to give the deprotected amine as the hydrochloride salt (0.405 g).
後処理
- concentrationthe solution was concentrated
出典と根拠
- ORDレコード
- ord-6b9e7cd97d9f45f3a4633b664eb91d39
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809336B2
反応ノート
読み込み中…