Hydrochloric Acid → Amiselimod(MT-1303) hydrochloride

HRID 2406023ノート

反応式

HRID 2406023 の反応式
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:35])([F:34])[F:33])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:37]>C(O)C>[ClH:37].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:33])([F:34])[F:35])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57704611HCID 57704611、化合物

生成物 1

HCID 67418070Amiselimod(MT-1303) hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

Compound 1-2 (640 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (492 mg) as white powder.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

出典と根拠

ORDレコード
ord-577b6134ed3a46919e97c51dd84d2667
出典データセット
uspto-grants-2014_08
特許番号
US08809304B2

反応ノート

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