Water → 4'-Methoxy-3'-(trifluoromethyl)acetophenone
反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][O-:16].[Na+].O>CN(C)C=O>[CH3:15][O:16][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12]参加物
5
実験手順
To a solution of 4′-fluoro-3′-trifluoromethylacetophenone (25.0 g) in N,N-dimethylformamide (70 ml) was added sodium methoxide (7.21 g) under ice-cooling, and the mixture was stirred for 2 hr under ice-cooling and further at room temperature for 1 hr. The reaction mixture was added to water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (24.3 g) as a brown solid.
後処理
- temperaturecooling
- extractionextracted with ethyl acetate
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-0a21122639dc46cca1066db45c2340b0
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809304B2
反応ノート
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