(S)-1-Phenylbutylamine → (S)-2-cyano-N-(1-phenylbutyl)acetamide
反応式
[C:1]([CH2:3][C:4]([NH:6][CH:7]([C:11]1[CH:16]=[CH:15][C:14](OCCN(CC)CC)=[CH:13][CH:12]=1)[CH2:8][CH2:9][CH3:10])=[O:5])#[N:2].C1([C@@H](N)CCC)C=CC=CC=1>>[C:1]([CH2:3][C:4]([NH:6][C@H:7]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:9][CH3:10])=[O:5])#[N:2]参加物
3
実験手順
The title compound was prepared by using a similar procedure as described for the preparation of 29 except that (S)-1-phenylbutylamine was used instead of 1-(4-(2-(diethylamino)ethoxy)phenyl)butan-1-amine (25). This produced crude product which was purified by flash silica gel column chromatography, eluting with 7:3 hexanes/ethyl acetate, to give 39 (375 mg, 58%) as a white solid: MS (ES+) m/z 217.1.1 (M+H)+.
後処理
- customThe title compound was prepared
- customThis produced crude product which
- customwas purified by flash silica gel column chromatography
- washeluting with 7:3 hexanes/ethyl acetate
出典と根拠
- ORDレコード
- ord-2bbccb3301ad4c8a967df9b2b3cdb307
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809377B2
反応ノート
読み込み中…