(E)-(2-(2-(2-(4-(1-(3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid, 1,3-bis-tert-butyl ester → N-(2-(2-(2-(4-(1-((E)-3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
反応式
[Br:1][C:2]1[N:7]=[C:6](/[CH:8]=[C:9](\C#N)/[C:10]([NH:12][CH:13]([C:17]2[CH:47]=[CH:46][C:20]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][NH:30][C:31](=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][C@H:36]3[C@@H:43]4[C@@H:39]([NH:40][C:41](=[O:44])[NH:42]4)[CH2:38][S:37]3)=[CH:19][CH:18]=2)[CH2:14][CH2:15][CH3:16])=[O:11])[CH:5]=[CH:4][CH:3]=1.BrC1N=C(/C=C/C(NC(C2C=CC(OCCOCCOCCN(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=CC=2)CCC)=O)C=CC=1>>[Br:1][C:2]1[N:7]=[C:6](/[CH:8]=[CH:9]/[C:10]([NH:12][CH:13]([C:17]2[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][NH:30][C:31](=[O:45])[CH2:32][CH2:33][CH2:34][CH2:35][C@H:36]3[C@@H:43]4[C@@H:39]([NH:40][C:41](=[O:44])[NH:42]4)[CH2:38][S:37]3)=[CH:46][CH:47]=2)[CH2:14][CH2:15][CH3:16])=[O:11])[CH:5]=[CH:4][CH:3]=1参加物
3
反応物 2
HCID 86762605(E)-(2-(2-(2-(4-(1-(3-(6-Bromopyridin-2-yl)acrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)imidodicarbonic acid, 1,3-bis-tert-butyl ester
HCID 87168264N-(2-(2-(2-(4-(1-((E)-3-(6-Bromopyridin-2-yl)-2-cyanoacrylamido)butyl)phenoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide生成物 1
実験手順
The title compound was prepared by using a similar procedure as described for the preparation of 48 except that acrylamide 50 was used instead of cyanoacrylamide 47. This produced the crude product which was purified by flash silica gel column chromatography, eluting with 7:93 methanol/dichloromethane, to give 51 (50 mg, quantitative) as a clear oil: MS (ES+) m/z 731.2 (M+H)+.
後処理
- customThis produced the crude product which
出典と根拠
- ORDレコード
- ord-9f2778eee3994103bb0b59c26655ed81
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08809377B2
反応ノート
読み込み中…