Lithium hydroxide, monohydrate → (3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

HRID 2406653ノート

反応式

HRID 2406653 の反応式
C[O:2][C:3](=[O:27])[CH2:4][C@H:5]([CH3:26])[CH2:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Cl:18])[CH:16]=2)[N:11]([CH3:19])[C:10]=1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:8].O.[OH-].[Li+]>C(O)(C)C.O>[Cl:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([CH3:19])[C:10]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[C:9]2[C:7](=[O:8])[CH2:6][C@@H:5]([CH3:26])[CH2:4][C:3]([OH:27])=[O:2]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 66644148Methyl 5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate

生成物 1

HCID 49802026(3R)-5-(5-chloro-2-hexyl-1-methylindol-3-yl)-3-methyl-5-oxopentanoic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3776Isopropanol溶媒

実験手順

To the solution of Methyl-5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-(R)-methyl-5-oxopentanoate in iso-propanol and water was added lithium hydroxide monohydrate and was stirred at RT for three hours. The product was purified by column chromatography.

後処理

  1. customThe product was purified by column chromatography

出典と根拠

ORDレコード
ord-e9ab8f561224433e8a012cb380e93e48
出典データセット
uspto-grants-2014_08
特許番号
US08809382B2

反応ノート

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